Your doctor may suggest that you have injections of Rh immunoglobulin (also known as RhoGAM in the US) during your pregnancy and once more soon after giving birth if you are expecting a kid who is Rh positive.

Despite how serious the word "Rh incompatibility" sounds, the treatment is straightforward and low-risk.

During prenatal testing, birth, or around week 28 of pregnancy, if your blood comes in contact with the baby's, your doctor could provide an injection of RhoGAM (generic name:

Immune globulin Rho(D)) to alleviate the symptoms temporarily. This informative RhoGAM shot article will assist you in understanding this rare phenomenon.

Rh Factor and Its Affect On Pregnancy

Rh Factor and Its Affect On Pregnancy

RBCs, which carry oxygen throughout the body, often include a protein called Rh factor on their surface. It is not, however, a protein that everyone has. A person is regarded as Rh positive if they possess the protein. If not, you have an Rh-negative blood type.

The great majority of humans have the Rh factor. Approximately 15% of white people, 4-8% of black people, and 0.3% of Asian people have a negative Rh factor.

If you've ever had blood taken or donated, you're certainly acquainted with the "+" or "-" at the end of your blood type. This indicator will appear if the Rh factor is present in your blood. For instance, the Rh factor is present in O+ blood but absent in O-blood.

It doesn't matter whether you are positive or negative unless you expect a kid.

When a woman is Rh negative, and her unborn child is Rh positive, this is known as Rh incompatibility. You may produce Rh antibodies if your blood mixes with that of your unborn child while you are pregnant or after delivery.

These Rh + red blood cells will be attacked by your immune system, which might lead to difficulties (particularly if you get pregnant with another Rh-positive baby in the future). An early pregnancy Rh factor test should be done as a result.

What Is A RhoGAM Shot?

Anti-D immune globulin is marketed under the trademarks RhIG and RhoGAM. It is a pharmaceutical item made from immunoglobulins isolated from human plasma in a sterile setting (the liquid part of the blood).

Patients with Rh-positive thrombocytopenic purpura may benefit from RhoGAM injections (ITP). To protect the health of their unborn offspring, it is also administered to expecting moms with Rh-negative blood types.

Why Is RhoGAM Shot Important?

The parent's blood may produce antibodies that target Rh-positive red blood cells during pregnancy if it comes into contact with the baby's blood. These antibodies may endanger a baby with an Rh-positive status due to the following reasons:

  • Infants who are anemic (low iron in the blood due to hemolysis)
  • Miscarriage
  • Stillbirth is a serious condition.
  • Jaundice (from high bilirubin due to hemolysis)

Due to the time it takes for antibodies to form, these effects are seldom seen in the first trimester, despite the possibility that they might harm any future Rh-positive children.

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Sensitization is the process that results in developing these antibodies; however, sensitization may be avoided by administering RhoGAM beforehand. RhoGAM is a sterile solution made from human blood that contains very small amounts of Rh-positive proteins. 3

The mother's blood type, Rh-factor, and, if necessary, antibody screening should be done as part of early prenatal care. It is uncommon to test the fetus' blood type.

A child born to Rh-positive parents will also be Rh-positive since the Rh-factor is inherited. Conversely, two Rh-negative parents ensure that their offspring will also be negative.

Any of these two parents might be the biological parents of a child born to a genetically positive mother and a genetically negative father.

Doctors will give a RhoGAM injection if the expectant parent is Rh-negative, their antibody test is negative, the other genetic parent is Rh-positive, or if their Rh-factor is unknown.

When To Receive A RhoGAM Vaccination?

Be skeptical that no danger exists with RhoGAM injections. However, it is safe because it has undergone rigorous clinical screening and sterilization.

The only method to prevent Rh incompatibility issues is with RhoGAM injections.

Women with Rh-negative blood between 26 and 28 are highly urged to have RhoGAM injections. Then, there will be a lower possibility of acquiring an Rh allergy. Your body will not create enough antibodies to damage your first kid before birth, but they might seriously interfere with subsequent pregnancies.

Whether you had a vaginal or surgical delivery, you will get another RhoGAM shot 72 hours after giving birth if your child is Rh-positive. This is because large volumes of blood mix and Rh sensitization occur during labor and delivery.

Your physician will urge you to have RhoGAM injections as soon as possible if you suffer from any of the following conditions:

  • Spotting or frequently bleeding in the first trimester
  • Accidents requiring a physical force to the abdomen, such as amniocentesis and CVS (chorionic villus sampling), are invasive and potentially dangerous procedures.
  • Abortions, ectopic pregnancies, and blood transfusions can have unfavorable results.
  • Techniques for manually turning a breech baby
When To Receive A RhoGAM Vaccination

Ideal Time To Get RhoGAM Shot

Although it is most likely to occur around the moment of birth, mother-to-child blood transfusions may also occur during the third trimester of pregnancy when the placenta is growing, and the membranes separating your blood from the baby's blood are very thin.

Due to this danger, RhoGAM is administered in week 28 to protect you for the remainder of your pregnancy. The 13-week active phase of RhoGAM is.

The doctors will examine your newborn's blood shortly after delivery to check for the Rh factor. Within 72 hours after giving birth, the mother will be given a double dosage of RhoGAM if the baby has Rh-positive blood.

If your child is Rh-negative, you will only need one RhoGAM injection during pregnancy.

When Is It Too Late To Get RhoGAM Shot?

The formation of antibodies against your baby's red blood cells by your body following sensitization prevents you from receiving a RhoGAM injection after giving birth.

Your blood will naturally blend after your first birth, so this won't be an issue. A person's ability to produce antibodies specific to Rh-positive blood takes around a month.

In contrast, having a second Rh-positive child might be very dangerous. You should know that complications during pregnancy, such as fetal erythroblastosis and hydrops fetalis, may have devastating effects on your unborn child.

What Would Happen If You Missed Your RhoGAM Shot?

Rh disease will not affect you, but missing the RhoGAM injection might put your baby and future children at risk.

In other words, one in five Rh-negative pregnant women will become sensitive to the Rh-positive factor without RhoGAM. This increases the likelihood that her unborn child may experience one or more of the following conditions:

  • A lack of healthy red blood cells that are known as anemia.
  • heart disease
  • brain injury
  • Jaundice, a yellowish tint to the skin and eyes caused by an inefficiently functioning liver, is frequent in infants.


If you learn that your blood type is Rh-negative, you should obtain the RhoGAM injection as soon as possible rather than waiting until the baby is delivered. You should get a second dosage within 72 hours if you recently gave birth to an Rh-positive kid.

If you took your first dosage during the first 28 weeks of pregnancy, even if it was late, there's no reason to be alarmed. The 13-week window during which RhoGAM is still active is nearly the window in which you will give birth. Unfortunately, it's too late to obtain a shot after you've been sensitized.

Once Rh sensitization has been established, either by blood tests or an ultrasound, your doctor will make frequent visits to check on your antibody levels and the development of your unborn child.

You must always remember that the RhoGAM injection is the only way to save your unborn child against a possibly deadly condition.

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